Lakers vs. Spurs prediction and odds for Wednesday, Dec. 13 (Bet the Over in San Antonio)

Victor Wembanyama and the San Antonio Spurs will play LeBron James and the Los Angeles Lakers tonight in the first of two games at Frost Bank Center over the next three days. It is the first time that we will see Wembanyama, who has set the NBA world on fire, take on James, one of the best players to play the game of basketball.

In addition to this highly anticipated matchup, the Spurs are looking to snap their 17-game losing streak, which includes nine straight losses at home. San Antonio is only 2.5-point underdogs for tonight's matchup as the Lakers are on the second night of a back-to-back.

Here are the odds and our best bet for Los Angeles-San Antonio:

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Lakers vs. Spurs odds, spread and total

Lakers vs. Spurs how to watch

• Date: Wednesday, Dec. 13
• Game Time: 8:00 p.m. EST
• Venue: Frost Bank Center
• How to Watch (TV): NBA TV
• Lakers Record: 14-10
• Spurs Record: 3-19

Lakers vs. Spurs injury reports

Los Angeles Lakers injury report

• Not submitted yet

San Antonio Spurs injury report

• Charles Bassey – Out

Lakers vs. Spurs key players to watch

Los Angeles Lakers

Austin Reaves: Reaves is putting on a show off the bench for the Lakers and is someone that teams have to gameplan for. In Tuesday night’s loss against the Mavericks, the 25-year-old had 22 points (7-14 FG, 4-7 3pt), eight assists, and five rebounds. Reaves has scored 20-plus points in three out of his last four games. He’s also averaging 19.3 points per game this month on 50% shooting from the field and 44% from three-point range.

San Antonio Spurs

Victor Wembanyama: Wembanyama continues to make unbelievable plays for the Spurs, even though they only have three wins this season. The rookie leads San Antonio in scoring (18.8 ppg) and rebounding (10.6 rpg). Wembanyama has recorded five double-doubles in five straight games, which includes a 21-point/20-rebound performance against the Bulls on Dec. 8. It will be fun to watch Wembanyama go up against LeBron James in their first meeting this season.

Lakers vs. Spurs prediction and pick

Currently, we don’t know who will play for the Lakers since it's the second night of a back-to-back. Los Angeles lost by two points to the Dallas Mavericks last night. Anthony Davis dropped 37 points and 11 rebounds in 37 minutes played. Meanwhile, James posted 33 points, nine assists, and eight rebounds in 40 minutes.

With the Lakers playing the Spurs again on Friday, it wouldn’t be surprising to see James or Davis sit. This season, Los Angeles is 1-3 straight up on the second night of back-to-back and 0-4 against the spread.

Meanwhile, the Spurs are in the middle of a 17-game losing streak – the second longest in the NBA this season. San Antonio has lost nine consecutive games at home and outscored by 9.2 points per game. The Spurs are still trying to figure out their identity with Wembanyama. However, Wembanyama doesn’t have to carry the scoring load alone, as the Spurs have Devin Vassell and Keldon Johnson.

With the possibility of James or Davis not playing tonight, it’s tempting to take the Spurs on the spread. But they are 2-7-1 ATS as a home underdog this season. Therefore, I’ll take the OVER as the Spurs are 9-2 to the over at home, while the Lakers are 7-5 to the over on the road. Also, in their last 10 games, San Antonio allows 117.7 points per game.

Game odds refresh periodically and are subject to change.